The findings are part of the U.K. Deciphering Developmental Disorders (DDD) study, which recruited children with undiagnosed developmental disorders between 2010-2015 to see if new genetic technologies can help doctors understand why patients get developmental disorders.
Austrian scientists have developed a method to individually barcode different cells before they are loaded onto a microfluidic chip, meaning that a greater number of cells cells can undergo RNA sequencing more quickly and at lower cost.
According to the scientists, miR-132 loss in AD inhibits the generation of new neurons at the hippocampus, where memories are initially formed. The scientists added, however, that miR-132 supplementation can facilitate the generation of new neurons, and thereby alleviate memory deficits in AD.
As part of the current NIH trial, adults who have been fully vaccinated with any of the three COVID-19 vaccines currently available in the U.S.—made by Pfizer, Moderna and Johnson & Johnson—will receive boosters made by Moderna.
While most NGS providers limit their annotated reports to one mutation-one drug associations that address targeted therapeutics, Cellworks’ biosimulation platform permits an assessment of all cancer therapies, including radiation, chemotherapy, and immunotherapy.
NIH researchers have discovered a single genetic cause of early-onset ALS and a novel, metabolism-associated, molecular pathway that may contribute to neurodegeneration in other forms of the disease.
Genomic changes following platinum chemotherapy for neuroblastoma can cause secondary cancers in treated children. The scientists involved in this discovery hope it may lead to treatment changes to prevent these cancers from forming.
A multi-country collaboration set up in Europe is using data sharing and multi-omics techniques to help improve diagnosis and outcomes for thousands of individuals with rare diseases of unknown molecular origin.
After analyzing 330 metabolism genes in a pre-clinical model of glioblastoma, MD Anderson researchers discovered that several enzymes involved in fatty acid metabolism were important for glioblastoma cells.
Within the infants’ stool samples, researchers discovered 409 different genes providing bacteria with resistance to 34 types of antibiotics. Furthermore, 167 of the 409 genes found are resistant to multiple types of antibiotics, including those classified as "critically important" by the WHO for being able to treat serious diseases in the future.