Students studying in the classroom including a disability boy

Non-Coding Gene Variants Linked with Developmental Disorders in Children

The findings are part of the U.K. Deciphering Developmental Disorders (DDD) study, which recruited children with undiagnosed developmental disorders between 2010-2015 to see if new genetic technologies can help doctors understand why patients get developmental disorders.
Sequencing of RNA molecules

Quicker and Cheaper Single Cell RNA Sequencing Method Developed

Austrian scientists have developed a method to individually barcode different cells before they are loaded onto a microfluidic chip, meaning that a greater number of cells cells can undergo RNA sequencing more quickly and at lower cost.
Berg will partner with Massachusetts General Hospital and Brigham and Women's Hospital to study potential biomarkers for Alzheimer's and other neurodegenerative disorders from Harvard Biomarker Study biospecimens. [Source:]

Alzheimer’s Disease Neuronal Damage May Be Alleviated by Specific mRNA Molecule

According to the scientists, miR-132 loss in AD inhibits the generation of new neurons at the hippocampus, where memories are initially formed. The scientists added, however, that miR-132 supplementation can facilitate the generation of new neurons, and thereby alleviate memory deficits in AD.
Injecting Vaccine.

NIH Begins COVID-19 Vaccine Booster Shot Trials

As part of the current NIH trial, adults who have been fully vaccinated with any of the three COVID-19 vaccines currently available in the U.S.—made by Pfizer, Moderna and Johnson & Johnson—will receive boosters made by Moderna.

Sponsored: Making NGS Actionable—Moving Oncology Beyond ‘One Mutation-One Drug’

While most NGS providers limit their annotated reports to one mutation-one drug associations that address targeted therapeutics, Cellworks’ biosimulation platform permits an assessment of all cancer therapies, including radiation, chemotherapy, and immunotherapy.
Neuron system

Genetic Variant Behind Early ALS Uncovered

NIH researchers have discovered a single genetic cause of early-onset ALS and a novel, metabolism-associated, molecular pathway that may contribute to neurodegeneration in other forms of the disease.
Real fluorescence microscopic view of human neuroblastoma cells

Neuroblastoma Therapy-Driven Genetic Changes Lead to Secondary Cancers

Genomic changes following platinum chemotherapy for neuroblastoma can cause secondary cancers in treated children. The scientists involved in this discovery hope it may lead to treatment changes to prevent these cancers from forming.
Sergi Beltran and Leslie Matalonga pictured in front of a supercomputer and servers that hosts the RD-Connect Genome-Phenome Analysis Platform. The platform is located at the Centro Nacional de Análisis Genómico - Centre for Genomic Regulation facilities in the Parc Cientific de Barcelona

International Data Sharing Project Aims to Improve Rare Disease Diagnostics

A multi-country collaboration set up in Europe is using data sharing and multi-omics techniques to help improve diagnosis and outcomes for thousands of individuals with rare diseases of unknown molecular origin.
Glioblastoma brain cancer, CT scan

Targeting Specific Enzyme May Improve Glioblastoma Therapy

After analyzing 330 metabolism genes in a pre-clinical model of glioblastoma, MD Anderson researchers discovered that several enzymes involved in fatty acid metabolism were important for glioblastoma cells.
Microbiotica will use its precision metagenomics microbiome platform in an up-to-$534 million-plus partnership with Genentech

Antibiotic Resistance Genes Found in Gut Microbiome of Infants of Mothers Prescribed Antibiotics

Within the infants’ stool samples, researchers discovered 409 different genes providing bacteria with resistance to 34 types of antibiotics. Furthermore, 167 of the 409 genes found are resistant to multiple types of antibiotics, including those classified as "critically important" by the WHO for being able to treat serious diseases in the future.


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