According to the scientists, miR-132 loss in AD inhibits the generation of new neurons at the hippocampus, where memories are initially formed. The scientists added, however, that miR-132 supplementation can facilitate the generation of new neurons, and thereby alleviate memory deficits in AD.
While most NGS providers limit their annotated reports to one mutation-one drug associations that address targeted therapeutics, Cellworks’ biosimulation platform permits an assessment of all cancer therapies, including radiation, chemotherapy, and immunotherapy.
A multi-country collaboration set up in Europe is using data sharing and multi-omics techniques to help improve diagnosis and outcomes for thousands of individuals with rare diseases of unknown molecular origin.
Researchers based in Madrid have identified a microRNA biomarker that can accurately diagnose patients with the cardiac inflammatory condition myocarditis, something that has been hard to diagnose accurately in the past.
To better understand and estimate infectiousness in COVID-19 patients, a team a team of European researchers analyzed the PCR samples of more than 25,000 COVID-19 cases in order to determine their “viral loads”—the total number of copies of the SARS-CoV-2 genome contained in the sample.
The technique aims to provide nearly the same sensitivity as conventional PCR but without the 30-40 minute heating and cooling cycles normally involved. As reported in ACS Nano, the postage stamp-sized plasmofluidic chip accomplished 40 heating and cooling cycles and fluorescence detection in five minutes.
A method developed in Austria called saliva analysis by RNA sequencing, or SARSeq, has the same accuracy as RT-PCR for detecting Covid-19, but can process thousands of samples over 48 hours and also identify individual samples after pooling.
This new test could kickstart testing expansion and it could be deployed in remote locations including clinics and airports, due to its ease of use and portability.
Bluestar said the equity funding will enable it to advance its clinical development and commercialization efforts for its platform, which applies machine learning and the DNA-based 5-hydroxymethylcytosine (5hmC) biomarker as a screening method to detect cancer in multiple organs in men and women.
Genetic missense variants in 398 genes play a role in autism spectrum disorder, according to a whole-exome analysis by Baylor College of Medicine that applied evolutionary methods to assess the contribution of different proteins.